Chemical ligation of oligonucleotides using an electrophilic phosphorothioester

We developed a new approach for chemical ligation of oligonucleotides using the electrophilic phosphorothioester (EPT) group. A nucleophilic phosphorothioate group on oligonucleotides was converted into the EPT group by treatment with Sanger's reagent (1-fluoro-2,4-dinitrobenzene). EPT oligonuc...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Maruyama, Hideto, Oikawa, Ryota, Hayakawa, Mayu, Takamori, Shono, Kimura, Yasuaki, Abe, Naoko, Tsuji, Genichiro, Matsuda, Akira, Shuto, Satoshi, Ito, Yoshihiro, Abe, Hiroshi
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2017
Assuntos:
Chemical Biology and Nucleic Acid Chemistry
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5499596/
https://ncbi.nlm.nih.gov/pubmed/28520986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx459
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