Chemical ligation of oligonucleotides using an electrophilic phosphorothioester

We developed a new approach for chemical ligation of oligonucleotides using the electrophilic phosphorothioester (EPT) group. A nucleophilic phosphorothioate group on oligonucleotides was converted into the EPT group by treatment with Sanger's reagent (1-fluoro-2,4-dinitrobenzene). EPT oligonuc...

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Dades bibliogràfiques
Publicat a:Nucleic Acids Res
Autors principals: Maruyama, Hideto, Oikawa, Ryota, Hayakawa, Mayu, Takamori, Shono, Kimura, Yasuaki, Abe, Naoko, Tsuji, Genichiro, Matsuda, Akira, Shuto, Satoshi, Ito, Yoshihiro, Abe, Hiroshi
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2017
Matèries:
Chemical Biology and Nucleic Acid Chemistry
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5499596/
https://ncbi.nlm.nih.gov/pubmed/28520986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx459
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