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Evolving Artificial Metalloenzymes via Random Mutagenesis
Random mutagenesis has the potential to optimize the efficiency and selectivity of protein catalysts without requiring detailed knowledge of protein structure; however, introducing synthetic metal cofactors complicates the expression and screening of enzyme libraries, and activity arising from free...
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| Publié dans: | Nat Chem |
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| Auteurs principaux: | , , , , , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2018
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5891097/ https://ncbi.nlm.nih.gov/pubmed/29461523 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchem.2927 |
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