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A General Method for Artificial Metalloenzyme Formation via Strain-Promoted Azide-Alkyne Cycloaddition

Strain-promoted azide-alkyne cycloaddition (SPAAC) can be used to generate artificial metalloenzymes (ArMs) from scaffold proteins containing a p-azido-L-phenylalanine (Az) residue and catalytically active bicyclononyne-substituted metal complexes. The high efficiency of this reaction allows rapid A...

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Bibliographic Details
Main Authors: Yang, Hao, Srivastava, Poonam, Zhang, Chen, Lewis, Jared C.
Format: Artigo
Language:Inglês
Published: 2013
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3996923/
https://ncbi.nlm.nih.gov/pubmed/24376040
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201300661
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