How chemoproteomics can enable drug discovery and development

Por Moellering, Raymond E., Cravatt, Benjamin F.
Publicado em 2012

Functional lysine modification by an intrinsically reactive primary glycolytic metabolite

Por Moellering, Raymond E., Cravatt, Benjamin F.
Publicado em 2013

An Activity-Based Imaging Probe for the Integral Membrane Hydrolase KIAA1363

Por Chang, Jae Won, Moellering, Raymond E., Cravatt, Benjamin F.
Publicado em 2011

Profiling Reactive Metabolites via Chemical Trapping and Targeted Mass Spectrometry

Por Chang, Jae Won, Lee, Gihoon, Coukos, John S., Moellering, Raymond E.
Publicado no Anal Chem (2016)

Inhibition of oncogenic Wnt signaling through direct targeting of β-catenin

Por Grossmann, Tom N., Yeh, Johannes T.-H., Bowman, Brian R., Chu, Qian, Moellering, Raymond E., Verdine, Gregory L.
Publicado em 2012

An activity-dependent proximity ligation platform for spatially resolved quantification of active enzymes in single cells

Por Li, Gang, Montgomery, Jeffrey E., Eckert, Mark A., Chang, Jae Won, Tienda, Samantha M., Lengyel, Ernst, Moellering, Raymond E.
Publicado no Nat Commun (2017)

Stapled peptide inhibitors of RAB25 target context-specific phenotypes in cancer

Por Mitra, Shreya, Montgomery, Jeffrey E., Kolar, Matthew J., Li, Gang, Jeong, Kang J., Peng, Bo, Verdine, Gregory L., Mills, Gordon B., Moellering, Raymond E.
Publicado no Nat Commun (2017)

Direct inhibition of the NOTCH transcription factor complex

Por Moellering, Raymond E., Cornejo, Melanie, Davis, Tina N., Del Bianco, Cristina, Aster, Jon C., Blacklow, Stephen C., Kung, Andrew L., Gilliland, D. Gary, Verdine, Gregory L., Bradner, James E.
Publicado em 2009

Evolving Artificial Metalloenzymes via Random Mutagenesis

Por Yang, Hao, Swartz, Alan M., Park, Hyun June, Srivastava, Poonam, Ellis-Guardiola, Ken, Upp, David M., Lee, Gihoon, Belsare, Ketaki, Gu, Yifan, Zhang, Chen, Moellering, Raymond E., Lewis, Jared C.
Publicado no Nat Chem (2018)