Stapled peptide inhibitors of RAB25 target context-specific phenotypes in cancer

Recent evidence has established a role for the small GTPase RAB25, as well as related effector proteins, in enacting both pro-oncogenic and anti-oncogenic phenotypes in specific cellular contexts. Here we report the development of all-hydrocarbon stabilized peptides derived from the RAB-binding FIP-...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nat Commun
Prif Awduron: Mitra, Shreya, Montgomery, Jeffrey E., Kolar, Matthew J., Li, Gang, Jeong, Kang J., Peng, Bo, Verdine, Gregory L., Mills, Gordon B., Moellering, Raymond E.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2017
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5610242/
https://ncbi.nlm.nih.gov/pubmed/28939823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-00888-8
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