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An all-atom model for stabilization of α-helical structure in peptides by hydrocarbon staples
Recent work has shown that the incorporation of an all-hydrocarbon “staple” into peptides can greatly increase their α-helix propensity, leading to an improvement in pharmaceutical properties such as proteolytic stability, receptor affinity and cell-permeability. Stapled peptides thus show promise a...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2009
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2735086/ https://ncbi.nlm.nih.gov/pubmed/19334772 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja805037p |
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