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Direct inhibition of the NOTCH transcription factor complex
Direct inhibition of transcription factor complexes remains a central challenge in the discipline of ligand discovery. In general, these proteins lack surface involutions suitable for high-affinity binding by small molecules. Here we report the design of synthetic, cell-permeable, stabilized α-helic...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2951323/ https://ncbi.nlm.nih.gov/pubmed/19907488 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature08543 |
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