Notch Signaling Specifies Megakaryocyte Development from Hematopoietic Stem Cells

In the hematopoietic system, Notch signaling specifies T cell lineage fate, in part through negative regulation of B cell and myeloid lineage development. However, we unexpectedly observed the development of megakaryocytes when using heterotypic cocultures of hematopoietic stem cells with OP9 cells...

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Bibliographic Details
Main Authors: Mercher, Thomas, Cornejo, Melanie G., Sears, Christopher, Kindler, Thomas, Moore, Sandra A., Maillard, Ivan, Pear, Warren S., Aster, Jon C., Gilliland, D. Gary
Format: Artigo
Language:Inglês
Published: 2008
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3970322/
https://ncbi.nlm.nih.gov/pubmed/18786418
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2008.07.010
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