Nitric oxide-mediated posttranslational modifications control neurotransmitter release by modulating complexin farnesylation and enhancing its clamping ability

Nitric oxide (NO) regulates neuronal function and thus is critical for tuning neuronal communication. Mechanisms by which NO modulates protein function and interaction include posttranslational modifications (PTMs) such as S-nitrosylation. Importantly, cross signaling between S-nitrosylation and pre...

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Udgivet i:PLoS Biol
Main Authors: Robinson, Susan W., Bourgognon, Julie-Myrtille, Spiers, Jereme G., Breda, Carlo, Campesan, Susanna, Butcher, Adrian, Mallucci, Giovanna R., Dinsdale, David, Morone, Nobuhiro, Mistry, Raj, Smith, Tim M., Guerra-Martin, Maria, Challiss, R. A. John, Giorgini, Flaviano, Steinert, Joern R.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2018
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5890968/
https://ncbi.nlm.nih.gov/pubmed/29630591
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.2003611
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