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Alterations in neuronal metabolism contribute to the pathogenesis of prion disease

Neurodegenerative conditions are characterised by a progressive loss of neurons, which is believed to be initiated by misfolded protein aggregations. During this time period, many physiological and metabolomic alterations and changes in gene expression contribute to the decline in neuronal function....

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Cell Death Differ
Hauptverfasser: Bourgognon, Julie-Myrtille, Spiers, Jereme G., Scheiblich, Hannah, Antonov, Alexey, Bradley, Sophie J., Tobin, Andrew B., Steinert, Joern R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2018
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6113283/
https://ncbi.nlm.nih.gov/pubmed/29915278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-018-0148-x
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