Inhibition of neuroinflammatory nitric oxide signaling suppresses glycation and prevents neuronal dysfunction in mouse prion disease

Several neurodegenerative diseases associated with protein misfolding (Alzheimer’s and Parkinson’s disease) exhibit oxidative and nitrergic stress following initiation of neuroinflammatory pathways. Associated nitric oxide (NO)-mediated posttranslational modifications impact upon protein functions t...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Bourgognon, Julie-Myrtille, Spiers, Jereme G., Robinson, Sue W., Scheiblich, Hannah, Glynn, Paul, Ortori, Catharine, Bradley, Sophie J., Tobin, Andrew B., Steinert, Joern R.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2021
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7958397/
https://ncbi.nlm.nih.gov/pubmed/33653950
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2009579118
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