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Manganese Upregulates Cellular Prion Protein and Contributes to Altered Stabilization and Proteolysis: Relevance to Role of Metals in Pathogenesis of Prion Disease

Prion diseases are fatal neurodegenerative diseases resulting from misfolding of normal cellular prion (PrP(C)) into an abnormal form of scrapie prion (PrP(Sc)). The cellular mechanisms underlying the misfolding of PrP(C) are not well understood. Since cellular prion proteins harbor divalent metal-b...

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書誌詳細
主要な著者: Choi, Christopher J., Anantharam, Vellareddy, Martin, Dustin P., Nicholson, Eric M., Richt, Jürgen A., Kanthasamy, Arthi, Kanthasamy, Anumantha G.
フォーマット: Artigo
言語:Inglês
出版事項: Oxford University Press 2010
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2871751/
https://ncbi.nlm.nih.gov/pubmed/20176619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfq049
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