Rbfox1 Regulates Synaptic Transmission Through the Inhibitory Neuron Specific vSNARE Vamp1

Dysfunction of the neuronal RNA binding protein RBFOX1 has been linked to epilepsy and autism spectrum disorders. Rbfox1 loss in mice leads to neuronal hyper-excitability and seizures, but the physiological basis for this is unknown. We identify the vSNARE protein Vamp1 as a major Rbfox1 target. Vam...

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Udgivet i:Neuron
Main Authors: Vuong, Celine K., Wei, Weizheng, Lee, Ji-Ann, Lin, Chia-Ho, Damianov, Andrey, de la Torre-Ubieta, Luis, Halabi, Reem, Otis, Klara Olofsdotter, Martin, Kelsey C., O’Dell, Thomas J., Black, Douglas L.
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5890944/
https://ncbi.nlm.nih.gov/pubmed/29621484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2018.03.008
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