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Splicing activation by Rbfox requires self-aggregation through its tyrosine-rich domain
Proteins of the Rbfox family act with a complex of proteins called the Large Assembly of Splicing Regulators, LASR. We find that Rbfox interacts with LASR via its C-terminal domain (CTD) and this domain is essential for its splicing activity. In addition to LASR recruitment, a low complexity (LC) se...
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| Publié dans: | Cell |
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| Auteurs principaux: | , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2017
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5553710/ https://ncbi.nlm.nih.gov/pubmed/28708999 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2017.06.022 |
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