Splicing activation by Rbfox requires self-aggregation through its tyrosine-rich domain

Proteins of the Rbfox family act with a complex of proteins called the Large Assembly of Splicing Regulators, LASR. We find that Rbfox interacts with LASR via its C-terminal domain (CTD) and this domain is essential for its splicing activity. In addition to LASR recruitment, a low complexity (LC) se...

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Detalhes bibliográficos
Publicado no:Cell
Main Authors: Ying, Yi, Wang, Xiao-Jun, Vuong, Celine K., Lin, Chia-Ho, Damianov, Andrey, Black, Douglas L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5553710/
https://ncbi.nlm.nih.gov/pubmed/28708999
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2017.06.022
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