TREM2 is a receptor for β-amyloid which mediates microglial function

Mutations in triggering receptor expressed on myeloid cells 2 (TREM2) have been linked to increased Alzheimer’s disease (AD) risk. Neurobiological functions of TREM2 as well as its pathophysiological ligands remain elusive. Here we found that TREM2 directly binds to β-amyloid (Aβ) oligomers with nan...

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Pubblicato in:Neuron
Autori principali: Zhao, Yingjun, Wu, Xilin, Li, Xiaoguang, Jiang, Lu-Lin, Gui, Xun, Liu, Yan, Sun, Yu, Zhu, Bing, Piña-Crespo, Juan C., Zhang, Muxian, Zhang, Ningyan, Chen, Xiaochun, Bu, Guojun, An, Zhiqiang, Huang, Timothy Y., Xu, Huaxi
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5889092/
https://ncbi.nlm.nih.gov/pubmed/29518356
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2018.01.031
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