Soluble TREM2 induces inflammatory responses and enhances microglial survival

Triggering receptor expressed on myeloid cells 2 (TREM2) is an innate immune receptor expressed in microglia in the brain. A soluble form of TREM2 (sTREM2) derived from proteolytic cleavage of the cell surface receptor is increased in the preclinical stages of AD and positively correlates with the a...

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Detalhes bibliográficos
Publicado no:J Exp Med
Main Authors: Zhong, Li, Chen, Xiao-Fen, Wang, Tingting, Wang, Zhe, Liao, Chunyan, Wang, Zongqi, Huang, Ruizhi, Wang, Daxin, Li, Xinxiu, Wu, Linbei, Jia, Lin, Zheng, Honghua, Painter, Meghan, Atagi, Yuka, Liu, Chia-Chen, Zhang, Yun-Wu, Fryer, John D., Xu, Huaxi, Bu, Guojun
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2017
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5339672/
https://ncbi.nlm.nih.gov/pubmed/28209725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20160844
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