Intracellular trafficking of TREM2 is regulated by presenilin 1

Genetic mutations in triggering receptor expressed on myeloid cells 2 (TREM2) have been linked to a variety of neurodegenerative diseases including Alzheimer’s disease, amyotrophic lateral sclerosis, frontotemporal dementia and Parkinson’s disease. In the brain, TREM2 is highly expressed on the cell...

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Udgivet i:Exp Mol Med
Main Authors: Zhao, Yingjun, Li, Xiaoguang, Huang, Timothy, Jiang, Lu-lin, Tan, Zhenqiu, Zhang, Muxian, Cheng, Irene Han-Juo, Wang, Xin, Bu, Guojun, Zhang, Yun-wu, Wang, Qi, Xu, Huaxi
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2017
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Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5750471/
https://ncbi.nlm.nih.gov/pubmed/29611543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emm.2017.200
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