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Trafficking regulation of proteins in Alzheimer’s disease
The β-amyloid (Aβ) peptide has been postulated to be a key determinant in the pathogenesis of Alzheimer’s disease (AD). Aβ is produced through sequential cleavage of the β-amyloid precursor protein (APP) by β- and γ-secretases. APP and relevant secretases are transmembrane proteins and traffic throu...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3891995/ https://ncbi.nlm.nih.gov/pubmed/24410826 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-9-6 |
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