Implications of GABAergic neurotransmission in Alzheimer’s disease

Alzheimer’s disease (AD) is characterized pathologically by the deposition of -amyloid peptides (A) and the accumulation of neurofibrillary tangles (NFTs) composed of hyper-phosphorylated tau. Regardless of the pathological hallmarks, synaptic dysfunction is widely accepted as a causal event in AD...

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Detalhes bibliográficos
Main Authors: Yanfang eLi, Hao eSun, Zhicai eChen, Huaxi eXu, Guojun eBu, Hui eZheng
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2016-02-01
Colecção:Frontiers in Aging Neuroscience
Assuntos:
Amyloid beta-Peptides
Apolipoproteins E
tau Proteins
gabaergic neurotransmission
neuronal inhibition
Acesso em linha:http://journal.frontiersin.org/Journal/10.3389/fnagi.2016.00031/full
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