The neurotoxin 1-methyl-4-phenylpyridinium (MPP+) alters hippocampal excitatory synaptic transmission by modulation of the GABAergic system

The neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) induces Parkinson’s disease (PD)-like symptoms following administration to mice, monkeys and humans. A common view is that MPTP is metabolized to 1-methyl-4-phenylpyridinium ion (MPP+) to induce its neurodegenerative effects on dopam...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: YuYing eHuang, JunFang eChen, Ying eChen, YingHan eZhuang, Mu eSun, Thomas eBehnisch
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2015-08-01
Colecção:Frontiers in Cellular Neuroscience
Assuntos:
Limbic System
dopaminergic system
tonic inhibition
synaptic transmission;
Parkinson’s disease (PD)
Extrasynaptic GABAergic receptors
Acesso em linha:http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00299/full
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados