The neurotoxin 1-methyl-4-phenylpyridinium (MPP(+)) alters hippocampal excitatory synaptic transmission by modulation of the GABAergic system

The neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) induces Parkinson’s disease-like symptoms following administration to mice, monkeys, and humans. A common view is that MPTP is metabolized to 1-methyl-4-phenylpyridinium ion (MPP(+)) to induce its neurodegenerative effects on dopamin...

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Udgivet i:Front Cell Neurosci
Main Authors: Huang, YuYing, Chen, JunFang, Chen, Ying, Zhuang, YingHan, Sun, Mu, Behnisch, Thomas
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2015
Fag:
Neuroscience
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4523793/
https://ncbi.nlm.nih.gov/pubmed/26300734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2015.00299
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