Changes in Neuronal Dopamine Homeostasis following 1-Methyl-4-phenylpyridinium (MPP(+)) Exposure

1-Methyl-4-phenylpyridinium (MPP(+)), the active metabolite of the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, selectively kills dopaminergic neurons in vivo and in vitro via a variety of toxic mechanisms, including mitochondrial dysfunction, generation of peroxynitrite, induction of ap...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Choi, Se Joon, Panhelainen, Anne, Schmitz, Yvonne, Larsen, Kristin E., Kanter, Ellen, Wu, Min, Sulzer, David, Mosharov, Eugene V.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Neurobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4358106/
https://ncbi.nlm.nih.gov/pubmed/25596531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.631556
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