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DNA sliding in nucleosomes via twist defect propagation revealed by molecular simulations

While nucleosomes are highly stable structures as fundamental units of chromatin, they also slide along the DNA, either spontaneously or by active remodelers. Here, we investigate the microscopic mechanisms of nucleosome sliding by multiscale molecular simulations, characterizing how the screw-like...

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Detalles Bibliográficos
Publicado en:Nucleic Acids Res
Main Authors: Brandani, Giovanni B, Niina, Toru, Tan, Cheng, Takada, Shoji
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2018
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5887990/
https://ncbi.nlm.nih.gov/pubmed/29506273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky158
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