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Partial Unwrapping and Histone Tail Dynamics in Nucleosome Revealed by Coarse-Grained Molecular Simulations

Nucleosomes, basic units of chromatin, are known to show spontaneous DNA unwrapping dynamics that are crucial for transcriptional activation, but its structural details are yet to be elucidated. Here, employing a coarse-grained molecular model that captures residue-level structural details up to his...

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Detalles Bibliográficos
Publicado en:PLoS Comput Biol
Main Authors: Kenzaki, Hiroo, Takada, Shoji
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2015
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4532510/
https://ncbi.nlm.nih.gov/pubmed/26262925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1004443
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