IKKβ and mutant huntingtin interactions regulate the expression of IL-34: implications for microglial-mediated neurodegeneration in HD

Neuronal interleukin-34 (IL-34) promotes the expansion of microglia in the central nervous system—microglial activation and expansion are in turn implicated in the pathogenesis of Huntington‘s disease (HD). We thus examined whether the accumulation of an amyloidogenic exon-1 fragment of mutant hunti...

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Detalhes bibliográficos
Publicado no:Hum Mol Genet
Main Authors: Khoshnan, Ali, Sabbaugh, Adam, Calamini, Barbara, Marinero, Steven A, Dunn, Denise E, Yoo, Jung Hyun, Ko, Jan, Lo, Donald C, Patterson, Paul H
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2017
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5886231/
https://ncbi.nlm.nih.gov/pubmed/28973132
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddx315
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