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IKKβ and mutant huntingtin interactions regulate the expression of IL-34: implications for microglial-mediated neurodegeneration in HD
Neuronal interleukin-34 (IL-34) promotes the expansion of microglia in the central nervous system—microglial activation and expansion are in turn implicated in the pathogenesis of Huntington‘s disease (HD). We thus examined whether the accumulation of an amyloidogenic exon-1 fragment of mutant hunti...
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| Publicat a: | Hum Mol Genet |
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| Autors principals: | , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Oxford University Press
2017
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5886231/ https://ncbi.nlm.nih.gov/pubmed/28973132 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddx315 |
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