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IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome
Expansion of the polyglutamine repeat within the protein Huntingtin (Htt) causes Huntington's disease, a neurodegenerative disease associated with aging and the accumulation of mutant Htt in diseased neurons. Understanding the mechanisms that influence Htt cellular degradation may target treatm...
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| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2806289/ https://ncbi.nlm.nih.gov/pubmed/20026656 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200909067 |
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