IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome

Expansion of the polyglutamine repeat within the protein Huntingtin (Htt) causes Huntington's disease, a neurodegenerative disease associated with aging and the accumulation of mutant Htt in diseased neurons. Understanding the mechanisms that influence Htt cellular degradation may target treatm...

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Detalhes bibliográficos
Main Authors: Thompson, Leslie Michels, Aiken, Charity T., Kaltenbach, Linda S., Agrawal, Namita, Illes, Katalin, Khoshnan, Ali, Martinez-Vincente, Marta, Arrasate, Montserrat, O'Rourke, Jacqueline Gire, Khashwji, Hasan, Lukacsovich, Tamas, Zhu, Ya-Zhen, Lau, Alice L., Massey, Ashish, Hayden, Michael R., Zeitlin, Scott O., Finkbeiner, Steven, Green, Kim N., LaFerla, Frank M., Bates, Gillian, Huang, Lan, Patterson, Paul H., Lo, Donald C., Cuervo, Ana Maria, Marsh, J. Lawrence, Steffan, Joan S.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2009
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2806289/
https://ncbi.nlm.nih.gov/pubmed/20026656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200909067
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