IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome

Expansion of the polyglutamine repeat within the protein Huntingtin (Htt) causes Huntington's disease, a neurodegenerative disease associated with aging and the accumulation of mutant Htt in diseased neurons. Understanding the mechanisms that influence Htt cellular degradation may target treatm...

Ful tanımlama

Kaydedildi:
Detaylı Bibliyografya
Asıl Yazarlar: Thompson, Leslie Michels, Aiken, Charity T., Kaltenbach, Linda S., Agrawal, Namita, Illes, Katalin, Khoshnan, Ali, Martinez-Vincente, Marta, Arrasate, Montserrat, O'Rourke, Jacqueline Gire, Khashwji, Hasan, Lukacsovich, Tamas, Zhu, Ya-Zhen, Lau, Alice L., Massey, Ashish, Hayden, Michael R., Zeitlin, Scott O., Finkbeiner, Steven, Green, Kim N., LaFerla, Frank M., Bates, Gillian, Huang, Lan, Patterson, Paul H., Lo, Donald C., Cuervo, Ana Maria, Marsh, J. Lawrence, Steffan, Joan S.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: The Rockefeller University Press 2009
Konular:
Research Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2806289/
https://ncbi.nlm.nih.gov/pubmed/20026656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200909067
Etiketler: Etiketle
Etiket eklenmemiş, İlk siz ekleyin!

Benzer Materyaller