A Two-Step Path to Inclusion Formation of Huntingtin Peptides Revealed by Number and Brightness Analysis

Protein aggregation is a hallmark of several neurodegenerative diseases including Huntington's disease. We describe the use of the recently developed number and brightness method (N&B) that uses confocal images to monitor aggregation of Huntingtin exon 1 protein (Httex1p) directly in living...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Ossato, Giulia, Digman, Michelle A., Aiken, Charity, Lukacsovich, Tamas, Marsh, J. Lawrence, Gratton, Enrico
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: The Biophysical Society 2010
Θέματα:
Spectroscopy, Imaging, and Other Techniques
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2884247/
https://ncbi.nlm.nih.gov/pubmed/20550921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2010.02.058
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