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Deletion of the huntingtin proline-rich region does not significantly affect normal huntingtin function in mice
The N-terminus of Huntingtin, the protein encoded by the Huntington’s disease gene, contains a stretch of polyglutamine residues that is expanded in Huntington’s disease. The polyglutamine stretch is flanked by two conserved protein domains in vertebrates: an N1-17 domain, and a proline-rich region...
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| Hlavní autoři: | , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2012
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3432989/ https://ncbi.nlm.nih.gov/pubmed/22956985 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JHD-2012-120016 |
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