HACE1 is essential for astrocyte mitochondrial function and influences Huntington disease phenotypes in vivo

Oxidative stress is a prominent feature of Huntington disease (HD), and we have shown previously that reduced levels of hace1 (HECT domain and Ankyrin repeat containing E3 ubiquitin protein ligase 1) in patient striatum may contribute to the pathogenesis of HD. Hace1 promotes the stability of Nrf2 a...

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Detalhes bibliográficos
Publicado no:Hum Mol Genet
Main Authors: Ehrnhoefer, Dagmar E, Southwell, Amber L, Sivasubramanian, Meenalochani, Qiu, Xiaofan, Villanueva, Erika B, Xie, Yuanyun, Waltl, Sabine, Anderson, Lisa, Fazeli, Anita, Casal, Lorenzo, Felczak, Boguslaw, Tsang, Michelle, Hayden, Michael R
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2018
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5886116/
https://ncbi.nlm.nih.gov/pubmed/29121340
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddx394
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