An enhanced Q175 knock-in mouse model of Huntington disease with higher mutant huntingtin levels and accelerated disease phenotypes

Huntington disease (HD) model mice with heterozygous knock-in (KI) of an expanded CAG tract in exon 1 of the mouse huntingtin (Htt) gene homolog genetically recapitulate the mutation that causes HD, and might be favoured for preclinical studies. However, historically these mice have failed to phenot...

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Udgivet i:Hum Mol Genet
Main Authors: Southwell, Amber L., Smith-Dijak, Amy, Kay, Chris, Sepers, Marja, Villanueva, Erika B., Parsons, Matthew P., Xie, Yuanyun, Anderson, Lisa, Felczak, Boguslaw, Waltl, Sabine, Ko, Seunghyun, Cheung, Daphne, Dal Cengio, Louisa, Slama, Ramy, Petoukhov, Eugenia, Raymond, Lynn A., Hayden, Michael R.
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2016
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5216613/
https://ncbi.nlm.nih.gov/pubmed/27378694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddw212
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