An enhanced Q175 knock-in mouse model of Huntington disease with higher mutant huntingtin levels and accelerated disease phenotypes

Huntington disease (HD) model mice with heterozygous knock-in (KI) of an expanded CAG tract in exon 1 of the mouse huntingtin (Htt) gene homolog genetically recapitulate the mutation that causes HD, and might be favoured for preclinical studies. However, historically these mice have failed to phenot...

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Bibliografske podrobnosti
izdano v:Hum Mol Genet
Main Authors: Southwell, Amber L., Smith-Dijak, Amy, Kay, Chris, Sepers, Marja, Villanueva, Erika B., Parsons, Matthew P., Xie, Yuanyun, Anderson, Lisa, Felczak, Boguslaw, Waltl, Sabine, Ko, Seunghyun, Cheung, Daphne, Dal Cengio, Louisa, Slama, Ramy, Petoukhov, Eugenia, Raymond, Lynn A., Hayden, Michael R.
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2016
Teme:
Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5216613/
https://ncbi.nlm.nih.gov/pubmed/27378694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddw212
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