An enhanced Q175 knock-in mouse model of Huntington disease with higher mutant huntingtin levels and accelerated disease phenotypes

Huntington disease (HD) model mice with heterozygous knock-in (KI) of an expanded CAG tract in exon 1 of the mouse huntingtin (Htt) gene homolog genetically recapitulate the mutation that causes HD, and might be favoured for preclinical studies. However, historically these mice have failed to phenot...

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Veröffentlicht in:Hum Mol Genet
Hauptverfasser: Southwell, Amber L., Smith-Dijak, Amy, Kay, Chris, Sepers, Marja, Villanueva, Erika B., Parsons, Matthew P., Xie, Yuanyun, Anderson, Lisa, Felczak, Boguslaw, Waltl, Sabine, Ko, Seunghyun, Cheung, Daphne, Dal Cengio, Louisa, Slama, Ramy, Petoukhov, Eugenia, Raymond, Lynn A., Hayden, Michael R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2016
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5216613/
https://ncbi.nlm.nih.gov/pubmed/27378694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddw212
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