An enhanced Q175 knock-in mouse model of Huntington disease with higher mutant huntingtin levels and accelerated disease phenotypes

Huntington disease (HD) model mice with heterozygous knock-in (KI) of an expanded CAG tract in exon 1 of the mouse huntingtin (Htt) gene homolog genetically recapitulate the mutation that causes HD, and might be favoured for preclinical studies. However, historically these mice have failed to phenot...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Hum Mol Genet
Egile Nagusiak: Southwell, Amber L., Smith-Dijak, Amy, Kay, Chris, Sepers, Marja, Villanueva, Erika B., Parsons, Matthew P., Xie, Yuanyun, Anderson, Lisa, Felczak, Boguslaw, Waltl, Sabine, Ko, Seunghyun, Cheung, Daphne, Dal Cengio, Louisa, Slama, Ramy, Petoukhov, Eugenia, Raymond, Lynn A., Hayden, Michael R.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Oxford University Press 2016
Gaiak:
Articles
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5216613/
https://ncbi.nlm.nih.gov/pubmed/27378694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddw212
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