The IDH1 Mutation-Induced Oncometabolite, 2-Hydroxyglutarate, May Affect DNA Methylation and Expression of PD-L1 in Gliomas

Background: Malignant gliomas are heterogeneous brain tumors with the potential for aggressive disease progression, as influenced by suppressive immunoediting. Given the success and enhanced potential of immune-checkpoint inhibitors in immunotherapy, we focused on the connections between genetic alt...

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Detalhes bibliográficos
Publicado no:Front Mol Neurosci
Main Authors: Mu, Luyan, Long, Yu, Yang, Changlin, Jin, Linchun, Tao, Haipeng, Ge, Haitao, Chang, Yifan E., Karachi, Aida, Kubilis, Paul S., De Leon, Gabriel, Qi, Jiping, Sayour, Elias J., Mitchell, Duane A., Lin, Zhiguo, Huang, Jianping
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5882817/
https://ncbi.nlm.nih.gov/pubmed/29643764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2018.00082
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