IMMU-56. CXCR1/2 MODIFIED CARs CO-OPT RADIATION-INDUCED IL-8 FOR ENHANCED CHEMOTAXIS OF THE CAR T CELLS AND MAXIMAL ANTI-TUMOR EFFICACY

BACKGROUND: Glioblastomas (GBM) are heterogeneous brain tumors with capacity for malignant propagation. The treatment options are confined to surgery and chemo/radiation with marginal efficacy, thus, identifying novel markers/targets and development of novel targeted therapeutics is requisite. Cance...

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Vydáno v:Neuro Oncol
Hlavní autoři: Jin, Linchun, Tao, Haipeng, Zhang, Wang, Long, Yu, Dyson, Kyle, Karachi, Aida, Deleyrolle, Loic, Sayour, Elias, Rahman, Maryam, Mitchell, Duane, Rajon, Didier, Yang, Changlin, Kubilis, Paul, Bova, Frank, Lin, Zhiguo, Huang, Jianping
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2018
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6216562/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy148.559
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