IMMU-15. A UNIQUE SELF-STIMULATIVE PROPERTY OF CD70 CAR ADVANCES T CELL FUNCTION AND ANTI-TUMOR RESPONSE IN GLIOBLASTOMA

BACKGROUND: Glioblastoma (GBM) is a refractory brain tumor that desperately needs new therapeutic interventions. Our group identified CD70 as a novel target of CAR-T therapy for this malignancy. We demonstrate that CD70 is overexpressed by low-/high-grade gliomas and associated with poor survival fo...

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Vydáno v:Neuro Oncol
Hlavní autoři: Jin, Linchun, Hou, Alicia, Tao, Haipeng, Karachi, Aida, Na, Meng, Lin, Zhiguo, Deleyrolle, Loic, Sayour, Elias, Mitchell, Duane, Huang, Jianping
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2019
Témata:
Immunology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6847285/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz175.509
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