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Diverse Engineered Heme Proteins Enable Stereodivergent Cyclopropanation of Unactivated Alkenes

[Image: see text] Developing catalysts that produce each stereoisomer of a desired product selectively is a longstanding synthetic challenge. Biochemists have addressed this challenge by screening nature’s diversity to discover enzymes that catalyze the formation of complementary stereoisomers. We s...

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Pubblicato in:ACS Cent Sci
Autori principali: Knight, Anders M., Kan, S. B. Jennifer, Lewis, Russell D., Brandenberg, Oliver F., Chen, Kai, Arnold, Frances H.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Chemical Society 2018
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5879470/
https://ncbi.nlm.nih.gov/pubmed/29632883
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acscentsci.7b00548
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