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A2E-associated cell death and inflammation in retinal pigmented epithelial cells from human induced pluripotent stem cells
Accumulation of lipofuscin in the retinal pigmented epithelium (RPE) is observed in retinal degenerative diseases including Stargardt disease and age-related macular degeneration. Bis-retinoid N-retinyl-N-retinylidene ethanolamine (A2E) is a major component of lipofuscin. A2E has been implicated in...
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| Veröffentlicht in: | Stem Cell Res |
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| Hauptverfasser: | , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2018
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5877810/ https://ncbi.nlm.nih.gov/pubmed/29358124 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.scr.2018.01.014 |
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