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A2E-associated cell death and inflammation in retinal pigmented epithelial cells from human induced pluripotent stem cells
Accumulation of lipofuscin in the retinal pigmented epithelium (RPE) is observed in retinal degenerative diseases including Stargardt disease and age-related macular degeneration. Bis-retinoid N-retinyl-N-retinylidene ethanolamine (A2E) is a major component of lipofuscin. A2E has been implicated in...
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| Опубликовано в: : | Stem Cell Res |
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| Главные авторы: | , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2018
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5877810/ https://ncbi.nlm.nih.gov/pubmed/29358124 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.scr.2018.01.014 |
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