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Acute Stress Responses Are Early Molecular Events of Retinal Degeneration in Abca4(−/−)Rdh8(−/−) Mice After Light Exposure
PURPOSE: Mice lacking ATP-binding cassette transporter 4 (ABCA4) and retinol dehydrogenase 8 (RDH8) mimic features of human Stargardt disease and age-related macular degeneration. RNA-sequencing of whole eyes was done to study early gene expression changes in Abca4(−/−)Rdh8(−/−) mice. METHODS: Abca4...
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| Udgivet i: | Invest Ophthalmol Vis Sci |
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| Main Authors: | , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
The Association for Research in Vision and Ophthalmology
2016
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4928696/ https://ncbi.nlm.nih.gov/pubmed/27315541 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.15-18993 |
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