A2E-associated cell death and inflammation in retinal pigmented epithelial cells from human induced pluripotent stem cells

Accumulation of lipofuscin in the retinal pigmented epithelium (RPE) is observed in retinal degenerative diseases including Stargardt disease and age-related macular degeneration. Bis-retinoid N-retinyl-N-retinylidene ethanolamine (A2E) is a major component of lipofuscin. A2E has been implicated in...

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Bibliografske podrobnosti
izdano v:Stem Cell Res
Main Authors: Parmar, Vipul M., Parmar, Tanu, Arai, Eisuke, Perusek, Lindsay, Maeda, Akiko
Format: Artigo
Jezik:Inglês
Izdano: 2018
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5877810/
https://ncbi.nlm.nih.gov/pubmed/29358124
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.scr.2018.01.014
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