A2E-associated cell death and inflammation in retinal pigmented epithelial cells from human induced pluripotent stem cells

Accumulation of lipofuscin in the retinal pigmented epithelium (RPE) is observed in retinal degenerative diseases including Stargardt disease and age-related macular degeneration. Bis-retinoid N-retinyl-N-retinylidene ethanolamine (A2E) is a major component of lipofuscin. A2E has been implicated in...

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Publicat a:Stem Cell Res
Autors principals: Parmar, Vipul M., Parmar, Tanu, Arai, Eisuke, Perusek, Lindsay, Maeda, Akiko
Format: Artigo
Idioma:Inglês
Publicat: 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5877810/
https://ncbi.nlm.nih.gov/pubmed/29358124
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.scr.2018.01.014
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