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Retinal Cell Type DNA Methylation and Histone Modifications Predict Reprogramming Efficiency and Retinogenesis in 3D Organoid Cultures

Diverse cell types can be reprogrammed into pluripotent stem cells by ectopic expression of Oct4 (Pou5f1), Klf4, Sox3, and Myc. Many of these induced pluripotent stem cells (iPSCs) retain memory, in terms of DNA methylation and histone modifications (epigenetic memory), of their cellular origins, an...

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Bibliographische Detailangaben
Veröffentlicht in:Cell Rep
Hauptverfasser: Wang, Lu, Hiler, Daniel, Xu, Beisi, AlDiri, Issam, Chen, Xiang, Zhou, Xin, Griffiths, Lyra, Valentine, Marc, Shirinifard, Abbas, Sablauer, András, Thiagarajan, Suresh, Barabas, Marie-Elizabeth, Zhang, Jiakun, Johnson, Dianna, Frase, Sharon, Dyer, Michael A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5872828/
https://ncbi.nlm.nih.gov/pubmed/29514090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.01.075
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