Retinal Cell Type DNA Methylation and Histone Modifications Predict Reprogramming Efficiency and Retinogenesis in 3D Organoid Cultures

Diverse cell types can be reprogrammed into pluripotent stem cells by ectopic expression of Oct4 (Pou5f1), Klf4, Sox3, and Myc. Many of these induced pluripotent stem cells (iPSCs) retain memory, in terms of DNA methylation and histone modifications (epigenetic memory), of their cellular origins, an...

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Publicat a:Cell Rep
Autors principals: Wang, Lu, Hiler, Daniel, Xu, Beisi, AlDiri, Issam, Chen, Xiang, Zhou, Xin, Griffiths, Lyra, Valentine, Marc, Shirinifard, Abbas, Sablauer, András, Thiagarajan, Suresh, Barabas, Marie-Elizabeth, Zhang, Jiakun, Johnson, Dianna, Frase, Sharon, Dyer, Michael A.
Format: Artigo
Idioma:Inglês
Publicat: 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5872828/
https://ncbi.nlm.nih.gov/pubmed/29514090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.01.075
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