Retinal Cell Type DNA Methylation and Histone Modifications Predict Reprogramming Efficiency and Retinogenesis in 3D Organoid Cultures

Diverse cell types can be reprogrammed into pluripotent stem cells by ectopic expression of Oct4 (Pou5f1), Klf4, Sox3, and Myc. Many of these induced pluripotent stem cells (iPSCs) retain memory, in terms of DNA methylation and histone modifications (epigenetic memory), of their cellular origins, an...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Wang, Lu, Hiler, Daniel, Xu, Beisi, AlDiri, Issam, Chen, Xiang, Zhou, Xin, Griffiths, Lyra, Valentine, Marc, Shirinifard, Abbas, Sablauer, András, Thiagarajan, Suresh, Barabas, Marie-Elizabeth, Zhang, Jiakun, Johnson, Dianna, Frase, Sharon, Dyer, Michael A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5872828/
https://ncbi.nlm.nih.gov/pubmed/29514090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.01.075
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