Comparative Quantification in Three-Dimensional Cultures reveals Epigenetic Memory and Higher Efficiency Retinogenesis in iPSCs Derived from Differentiated Rod Photoreceptors

Cell-based therapies to treat retinal degeneration are now being tested in clinical trials. However, it is not known if the source of stem cells is important for the production of differentiated cells suitable for transplantation. To test this, we generated iPSCs murine rod photoreceptors (r-iPSCs)...

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Vydáno v:Cell Stem Cell
Hlavní autoři: Hiler, Daniel, Chen, Xiang, Hazen, Jennifer, Kupriyanov, Sergey, Carroll, Patrick A., Qu, Chunxu, Xu, Beisi, Johnson, Dianna, Griffiths, Lyra, Frase, Sharon, Rodriguez, Alberto R., Martin, Greg, Zhang, Jiakun, Jeon, Jongrye, Fan, Yiping, Finkelstein, David, Eisenman, Robert N., Baldwin, Kristin, Dyer, Michael A.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4547539/
https://ncbi.nlm.nih.gov/pubmed/26140606
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2015.05.015
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