Comparative Quantification in Three-Dimensional Cultures reveals Epigenetic Memory and Higher Efficiency Retinogenesis in iPSCs Derived from Differentiated Rod Photoreceptors

Cell-based therapies to treat retinal degeneration are now being tested in clinical trials. However, it is not known if the source of stem cells is important for the production of differentiated cells suitable for transplantation. To test this, we generated iPSCs murine rod photoreceptors (r-iPSCs)...

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Publicado en:Cell Stem Cell
Autores principales: Hiler, Daniel, Chen, Xiang, Hazen, Jennifer, Kupriyanov, Sergey, Carroll, Patrick A., Qu, Chunxu, Xu, Beisi, Johnson, Dianna, Griffiths, Lyra, Frase, Sharon, Rodriguez, Alberto R., Martin, Greg, Zhang, Jiakun, Jeon, Jongrye, Fan, Yiping, Finkelstein, David, Eisenman, Robert N., Baldwin, Kristin, Dyer, Michael A.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2015
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4547539/
https://ncbi.nlm.nih.gov/pubmed/26140606
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2015.05.015
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