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Reliability of algorithmic somatic copy number alteration detection from targeted capture data

MOTIVATION: Whole exome and gene panel sequencing are increasingly used for oncological diagnostics. To investigate the accuracy of SCNA detection algorithms on simulated and clinical tumor samples, the precision and sensitivity of four SCNA callers were measured using 50 simulated whole exome and 5...

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Publicat a:Bioinformatics
Autors principals: Rieber, Nora, Bohnert, Regina, Ziehm, Ulrike, Jansen, Gunther
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2017
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5870863/
https://ncbi.nlm.nih.gov/pubmed/28472276
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/bioinformatics/btx284
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