AAVrh.10-Mediated APOE2 Central Nervous System Gene Therapy for APOE4-Associated Alzheimer's Disease

Alzheimer's disease (AD) is a progressive degenerative neurological disorder affecting nearly one in nine elderly people in the United States. Population studies have shown that an inheritance of the apolipoprotein E (APOE) variant APOE4 allele increases the risk of developing AD, whereas APOE2...

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Vydáno v:Hum Gene Ther Clin Dev
Hlavní autoři: Rosenberg, Jonathan B., Kaplitt, Michael G., De, Bishnu P., Chen, Alvin, Flagiello, Thomas, Salami, Christiana, Pey, Eduard, Zhao, Lingzhi, Ricart Arbona, Rodolfo J., Monette, Sebastien, Dyke, Jonathan P., Ballon, Douglas J., Kaminsky, Stephen M., Sondhi, Dolan, Petsko, Gregory A., Paul, Steven M., Crystal, Ronald G.
Médium: Artigo
Jazyk:Inglês
Vydáno: Mary Ann Liebert, Inc. 2018
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5870071/
https://ncbi.nlm.nih.gov/pubmed/29409358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/humc.2017.231
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