AAVrh.10-Mediated APOE2 Central Nervous System Gene Therapy for APOE4-Associated Alzheimer's Disease

Alzheimer's disease (AD) is a progressive degenerative neurological disorder affecting nearly one in nine elderly people in the United States. Population studies have shown that an inheritance of the apolipoprotein E (APOE) variant APOE4 allele increases the risk of developing AD, whereas APOE2...

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Detalhes bibliográficos
Publicado no:Hum Gene Ther Clin Dev
Main Authors: Rosenberg, Jonathan B., Kaplitt, Michael G., De, Bishnu P., Chen, Alvin, Flagiello, Thomas, Salami, Christiana, Pey, Eduard, Zhao, Lingzhi, Ricart Arbona, Rodolfo J., Monette, Sebastien, Dyke, Jonathan P., Ballon, Douglas J., Kaminsky, Stephen M., Sondhi, Dolan, Petsko, Gregory A., Paul, Steven M., Crystal, Ronald G.
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5870071/
https://ncbi.nlm.nih.gov/pubmed/29409358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/humc.2017.231
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